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殷杰,理查德·温伯格,刘家伟,周汉昭,张宝林,夏运成,王继贵,梁燕玲,许树梧,冯清泉.茵栀黄对动物高间接胆红素血症的胆红素排泄作用[J].,1989,(5):289-291,262
茵栀黄对动物高间接胆红素血症的胆红素排泄作用
Effect of Yin Zhi Huang on Bilirubin Excretion in Animals with Unconjugated Hyperbilirubinemia
  
DOI:
中文关键词:  苯巴比妥钠  高间接胆红素血症  胆红素测定  茵桅黄  总胆红素  茵栀黄  直接胆红素  新生儿胆红素  动物血浆  胆红素含量
英文关键词:
基金项目:
Author NameAffiliation
Yin Jie 湖南医科大学第二附属医院儿科 
Hunan Medical 湖南医科大学第二附属医院儿科 
刘家伟 湖南医科大学第二附属医院儿科 
周汉昭 湖南医科大学第二附属医院儿科 
张宝林 湖南医科大学第二附属医院儿科 
夏运成 湖南医科大学第二附属医院检验科 
王继贵 湖南医科大学第二附属医院检验科 
梁燕玲 湖南医科大学第二附属医院药剂科 
许树梧 湖南医科大学第二附属医院药剂科 
冯清泉 湖南医科大学第二附属医院动物实验室 
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中文摘要:
      兔灌胃茵栀黄3天,可加速注入的非结合胆红素自血浆排泄;苯巴比妥灌胃3天可产生类似的作用,但较弱。给大白鼠腹腔内注射茵栀黄或苯巴比妥3天,并结扎其胆总管,茵栀黄或苯巴比妥处理的动物其间接胆红素水平较对照组为低,而肝胆红素含量和血浆直接胆红素水平增高。提示菌栀黄和苯巴比妥具有相同的降低血清间接胆红素的作用。
英文摘要:
      Yin Zhi Huang(YZH)given stomach perfusion daily for three days in rabbits accelerated plasma clearance of infused unconjugated bilirubin.A similar but less dramatic effect could be obtained by using YZH or phenobarbital i.p.daily for three days in rats employing simultaneously with the method of bile duct ligation,plasma indirect bilirubin levels was lower but hepatic bilirubin content and plasma direct bilirubin levels were higher in both YZH and phenobarbital treated rats than those in the control animals.These observations suggested that YZH and phenobarbital shared a common mechanism of acting in lowering the indirect bilirubin levels of serum.
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