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Systematic review on randomized controlled trials of coronary heart disease complicated with depression treated with Chinese herbal medicines

  • Evidence-Based Integrative Medicine
  • Published:
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Abstract

Objectives

This systemic review evaluated the efficacy and safety of Chinese herbal medicines (CHMs) in patients with coronary heart disease (CHD) complicated with depression.

Methods

All databases were retrieved till September 30, 2014. Randomized controlled trials (RCTs) comparing CHMs with placebo or conventional Western medicine were retrieved. Data extraction, analyses and quality assessment were performed according to the Cochrane standards. RevMan 5.3 was used to synthesize the results.

Results

Thirteen RCTs enrolling 1,095 patients were included. Subgroup analysis was used to assess data. In reducing the degree of depression, CHMs showed no statistic difference in the 4th week [mean difference (MD)=–1.06; 95% confidence interval (CI)–2.38 to 0.26; n=501; I2=73%], but it was associated with a statistically significant difference in the 8th week (MD=–1.00; 95% CI–1.64 to–0.36; n=436; I2=48%). Meanwhile, the combination therapy (CHMs together with antidepressants) showed significant statistic differences both in the 4th week (MD=–1.99; 95% CI–3.80 to–0.18; n=90) and in the 8th week (MD=–5.61; 95% CI–6.26 to–4.97; n=242; I2=87%). In CHD-related clinical evaluation, 3 trials reported the intervention group was superior to the control group. Four trials showed adverse events in the intervention group was less than that in the control group.

Conclusions

CHMs showed potentially benefits on patients with CHD complicated with depression. Moreover, the effect of CHMs may be similar to or better than antidepressant in certain fields but with less side effects. However, because of small sample size and potential bias of most trials, this result should be interpreted with caution. More rigorous trials with larger sample size and higher quality are warranted to give high quality of evidence to support the use of CHMs for CHD complicated with depression.

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Authors and Affiliations

  1. Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China

    An-lu Wang  (王安璐), Zhuo Chen  (陈 卓) & Jing Luo  (罗 静)

  2. Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China

    Qing-hua Shang  (尚青华) & Hao Xu  (徐 浩)

Authors
  1. An-lu Wang  (王安璐)
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  2. Zhuo Chen  (陈 卓)
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  3. Jing Luo  (罗 静)
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  4. Qing-hua Shang  (尚青华)
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  5. Hao Xu  (徐 浩)
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Corresponding author

Correspondence to Hao Xu  (徐 浩).

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Wang, Al., Chen, Z., Luo, J. et al. Systematic review on randomized controlled trials of coronary heart disease complicated with depression treated with Chinese herbal medicines. Chin. J. Integr. Med. 22, 56–66 (2016). https://doi.org/10.1007/s11655-015-2110-9

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  • DOI: https://doi.org/10.1007/s11655-015-2110-9

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