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Combination treatment with herbal medicines and Western medicines in atopic dermatitis: Benefits and considerations

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Abstract

Herbal medicines (HMs) are often used in combination with Western medicines (WMs) to improve therapeutic efficacies of orthodox medicines. This review discussed the current status of combination treatment with HMs and WMs in clinical practices. The influence of HMs on bioavailability of WMs was also discussed from the pharmacokinetic point of view. In addition, benefits and considerations of combination treatment were discussed using data obtained from clinical trials and randomized controlled trials of HMs treatment in skin diseases.

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References

  1. Chen HY, Lin YH, Wu JC, Hu S, Yang SH, Chen JL, et al. Use of traditional Chinese medicine reduces exposure to corticosteroid among atopic dermatitis children: a 1-year follow-up cohort study. J Ethnopharmacol 2015;159:189–196.

    Article  PubMed  Google Scholar 

  2. Zhang CS, Yu JJ, Parker S, Zhang AL, May B, Lu C, et al. Oral Chinese herbal medicine combined with pharmacotherapy for psoriasis vulgaris: a systematic review. Int J Dermatol 2014;53:1305–1318.

    Article  CAS  PubMed  Google Scholar 

  3. Li S, Kuchta K, Tamaru N, Lin Y, Iwasaki S, Wang R, et al. Efficacy of a novel herbal multicomponent traditional Chinese medicine therapy approach in patients with atopic dermatitis. Forsch Komplementmed 2013;20:189–196.

    Article  CAS  PubMed  Google Scholar 

  4. Smith N, Shin DB, Brauer JA, Mao J, Gelfand JM. Use of complementary and alternative medicine among adults with skin disease: results from a national survey. J Am Acad Dermatol 2009;60:419–425.

    Article  PubMed  Google Scholar 

  5. Hoare C, Li Wan Po A, Williams H. Systematic review of treatments for atopic eczema. Health Technol Assess 2000;4:1–191.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Gu S, Yang AW, Li CG, Lu C, Xue CC. Topical application of Chinese herbal medicine for atopic eczema: a systematic review with a meta-analysis. Dermatology 2014;228:294–302.

    Article  PubMed  Google Scholar 

  7. Gu S, Yang AW, Xue CC, Li CG, Pang C, Zhang W, et al. Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev 2013;9:CD008642.

    PubMed  Google Scholar 

  8. Perharic L, Shaw D, Leon C, De Smet PA, Murray VS. Possible association of liver damage with the use of Chinese herbal medicine for skin disease. Vet Hum Toxicol 1995;37:562–566.

    CAS  PubMed  Google Scholar 

  9. Oh SJ, Cho JH, Son CG. Systematic review of the incidence of herbal drug-induced liver injury in Korea. J Ethnopharmacol 2015;159:253–256.

    Article  PubMed  Google Scholar 

  10. Sheehan MP, Rustin MH, Atherton DJ, Buckley C, Harris DW, Brostoff J, et al. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Lancet 1992;340:13–17.

    Article  CAS  PubMed  Google Scholar 

  11. Sheehan MP, Atherton DJ. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. Br J Dermatol 1992;126:179–184.

    Article  CAS  PubMed  Google Scholar 

  12. Mao H, Mao YH. Clinical observation of integration of Chinese medicine and Western medicine treatment for psoriasis vulgaris. China Health Innov (Chin) 2007;19:64.

    Google Scholar 

  13. Kong HY. Clinical observation of integration of traditional and Western medicine for psoriasis. Inner Mongolia J Tradit Chin Med (Chin) 2007;3:22–23.

    Google Scholar 

  14. Teelucksingh S, Mackie ADR, Burt D, McIntyre MA. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 1990;335:1060–1063.

    Article  CAS  PubMed  Google Scholar 

  15. Kageyama Y, Suzuki H, Saruta T. Glycyrrhizin induces mineralocorticoid activity through alterations in cortisol metabolism in the human kidney. J Endocrinol 1992;135:147–152.

    Article  CAS  PubMed  Google Scholar 

  16. Soma R, Ikeda M, Morise T, Miyamori I, Takeda R. Effect of glycyrrhizin on cortisol metabolism in humans. Endocr Regul 1994;28:31–34.

    CAS  PubMed  Google Scholar 

  17. Krähenbühl S, Hasler F, Frey BM, Frey FJ, Brenneisen R, Krapf R. Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans. J Clin Endocrinol Metab 1994;78:581–585.

    PubMed  Google Scholar 

  18. Chen MF, Shimada F, Kato H, Yano S, Kanaoka M. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Jpn 1990;37:331–341.

    Article  CAS  PubMed  Google Scholar 

  19. Chen MF, Shimada F, Kato H, Yano S, Kanaoka M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Endocrinol Jpn 1991;38:167–174.

    Article  CAS  PubMed  Google Scholar 

  20. Ojima M, Satoh K, Gomibuchi T, Itoh N, Kin S, Fukuchi S, et al. The inhibitory effects of glycyrrhizin and glycyrrhetinic acid on the metabolism of cortisol and prednisolone—in vivo and in vitro studies. Folia Endocrinol Jap 1990;66:584–596.

    Article  CAS  Google Scholar 

  21. Homma M, Oka K, Ikeshima K, Takahashi N, Niitsuma T, Fukuda T, et al. Different effects of traditional Chinese medicines containing similar herbal constituents on prednisolone pharmacokinetics. J Pharm Pharmacol 1995;47:687–692.

    Article  CAS  PubMed  Google Scholar 

  22. Frey BM, Seeberger M, Frey FJ. Pharmacokinetics of 3 prednisolone prodrugs: evidence of therapeutic inequivalence in renal transplant patients with rejection. Transplantation 1985;39:270–274.

    Article  CAS  PubMed  Google Scholar 

  23. Kuhn MA. Herbal remedies: drug-herb interactions. Crit Care Nurse 2002;22:22–35.

    PubMed  Google Scholar 

  24. Ploeger B, Mensinga T, Sips A, Deerenberg C, Meulenbelt J, DeJongh J. A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-β-hydroxysteroid dehydrogenase activity by glycyrrhetic acid. Toxicol Appl Pharmacol 2001;170:46–55.

    Article  CAS  PubMed  Google Scholar 

  25. Makino T, Ohtake N, Watanabe A, Tsuchiya N, Imamura S, Iizuka S, et al. Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury. Drug Metab Dispos 2008;36:1438–1443.

    Article  CAS  PubMed  Google Scholar 

  26. Brooks SM, Sholiton LJ, Werk EE Jr, Altenau P. The effects of ephedrine and theophylline on dexamethasone metabolism in bronchial asthma. J Clin Pharmacol 1977;176:308–318.

    Article  Google Scholar 

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Correspondence to Hyungwoo Kim.

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Supported by the National Research Foundation of Korea Grant Funded by the Korean government (MSIP; No. 2014R1A5A2009936 and 2015R1A2A2A04005619)

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Kim, JH., Kim, H. Combination treatment with herbal medicines and Western medicines in atopic dermatitis: Benefits and considerations. Chin. J. Integr. Med. 22, 323–327 (2016). https://doi.org/10.1007/s11655-016-2099-0

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  • DOI: https://doi.org/10.1007/s11655-016-2099-0

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