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Effect of two administration routes of Shenmai Injection (参麦注射液) on pulmonary gas exchange function after tourniquet-induced ischemia-reperfusion

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Abstract

Objective

To compare the effect between nebulized and intravenous administration of Shenmai Injection (参麦注射液) on pulmonary gas exchange function of patients following tourniquet-induced lower limb ischemia-reperfusion.

Methods

Thirty-eight patients scheduled for lower extremity surgery were randomized into three groups using the closed envelop method: Shenmai Injection was administered 30 min before tourniquet inflflation by nebulization [0.6 mL/kg in 10 mL normal saline (NS)] in the nebulization group or by intravenous drip (0.6 mL/kg dissolved in 250 mL of 10% glucose) in the intravenous drip group, and equal volume of NS was given intravenously in the NS group; 15 in each group. Arterial blood gases were analyzed, serum levels of malonaldehyde (MDA) and interleukine-6 (IL-6) and interleukine-8 (IL-8) were determined using the method of thiobarbituric acid reaction and enzyme-linked immuno sorbent assay respectively just before tourniquet inflflation (T0), and at 0.5 h (T1), 2 h (T2), 6 h (T3) after tourniquet deflflation.

Results

Compared with baselines at T0, MDA levels signifificantly increased at T2, T3 in the NS group and at T3 in the nebulization group, and IL-6 and IL-8 levels were signifificantly increased at T2, T3 in NS, the intravenous drip and the nebulization groups (P <0.05). Arterial pressure of oxygen (PaO2) at T3 was decreased, while alveolararterial oxygen tension showed difference (PA-aDO2) at T3 in the NS group; RI at T3 in both intravenous drip and the nebulization groups were enhanced (P <0.05). Compared with the NS group, MDA and IL-8 levels at T2, T3, IL-6 at T3 in the intravenous drip group, and IL-8 at T3 in the nebulization group were all remarkably increased (P <0.05). Additionally, MDA level at T3 in the nebulization group was higher than that in the intravenous drip group (P <0.05).

Conclusions

Intravenous administration of Shenmai Injection provided a better protective effect than nebulization in mitigating pulmonary gas exchange dysfunction in patients following tourniquet-induced limb ischemia-reperfusion.

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Authors and Affiliations

  1. Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou Zhejiang, 325000, China

    Jian-guo Jin, Hai-jian Shen, Yuan-lu Shan, Lei Chen, Xi-yue Zhao, Liang-rong Wang & Li-na Lin

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  1. Jian-guo Jin
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  2. Hai-jian Shen
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  4. Lei Chen
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  6. Liang-rong Wang
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  7. Li-na Lin
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Correspondence to Li-na Lin.

Additional information

Supported by the Administration of Traditional Chinese Medicine Scientific Research of Zhejiang Province (No. 2010ZA087)

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Jin, Jg., Shen, Hj., Shan, Yl. et al. Effect of two administration routes of Shenmai Injection (参麦注射液) on pulmonary gas exchange function after tourniquet-induced ischemia-reperfusion. Chin. J. Integr. Med. 23, 18–24 (2017). https://doi.org/10.1007/s11655-016-2475-4

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  • DOI: https://doi.org/10.1007/s11655-016-2475-4

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