Skip to main content
SpringerLink
Log in

Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock

  • Original Article
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Objectives

To investigate the effect of Shenfu Injection (参附注射液, SFI) on inflammatory factors in patients with acute myocardial infarction complicated by cardiogenic shock (CS) treated with and intra-aortic balloon pump (IABP).

Methods

This study enrolled 60 patients with ST-segment elevation myocardial infarction (STEMI) complicated by CS. Patients underwent IABP and emergency percutaneous coronary intervention (PCI) were randomly divided into two groups by random number table with 30 cases in each group, one given Sfitreatment (100 mL/24 h), one not. The two groups were then compared in a clinical setting for left ventricular function, biochemical indicators and Inflammatory factors, including C-reactive proteins (CRP), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α). Major adverse cardiac and cerebrovascular events (MACCE) events were compared between patients of the two groups both in-hospital and in follow-ups.

Results

The IABP support treatment times of patients in the IABP+Sfigroup were signifificantly shorter than the IABP group (52.87±28.84 vs. 87.45±87.31, P=0.047). In the patients of the IABP+Sfigroup, the CRP peak appeared in 24 h after PCI operation. The CRP peak in the patients of the IABP+Sfigroup was signifificantly lower than that in the IABP group (31.27±3.93 vs. 34.62±3.47, P=0.001). The increases in range of TNF-α in the patients of the IABP+Sfigroup were signifificantly lower than those of the IABP group (182.29±22.79 vs. 195.54±12.02, P=0.007). The increases in range of IL-1 in the patients of the IABP+Sfigroup were signifificantly lower than those of the IABP group (214.98±29.22 vs. 228.60±7.03, P=0.019). The amplitude elevated TNF-α 72 h after admission was an independent risk factor of in-hospital MACCE events (OR 0.973, 95% CI 0.890–0.987, P=0.014) in patients with STEMI and CS.

Conclusion

Patients with STEMI complicated by CS treated by IABP and Sfihad a reduced inflammatory reaction, a reduced dependence of CS on IABP and shortened the course of disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hasdai D, Topol EJ, Califf RM, Berger PB, Holmes DR. Cardiogenic shock complicating acute coronary syndromes. Lancet 2000;356: 749–756.

    Article  CAS  PubMed  Google Scholar 

  2. Thiele H, Allam B, Chatellier G, Schuler G, Lafont A. Shock in acute myocardial infarction: the cape horn for trials. Eur Heart J 2010;31: 1828–1835.

    Article  PubMed  Google Scholar 

  3. Oconnor CM, Rogers JC. Evidence for overturning the guidelines in cardiogenic shock. N Engl J Med 2012;367: 1349–1350.

    Article  CAS  Google Scholar 

  4. Prondizinsky R, Lemm H, Swyter M, Wegener N, Unverzagt S, Carter JM, et al. Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicate by cardiogenic shock: the prospective, randmonized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome. Crit Care Med 2010;38: 152–160.

    Article  Google Scholar 

  5. Hochman JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation 2003;107: 2998–3002.

    Article  PubMed  Google Scholar 

  6. Yang QC, Mao W, Liu XS, Bao K, Zou Li C,et al. Systematic review on efficacy and safety of Shenfu Injection for cardiogenic shock. China J Tradit Chin Med Pharm (Chin) 2012;27: 1052–1059.

    Google Scholar 

  7. Qiu ZL, Ye YP, Zhang N. Clinical efficacy of Shenfu Injection in treating severe sepsis and its effects on serum levels of interleukin-6 and interleukin-10. Chin J Integr Tradit West Med (Chin) 2012;32: 348–351.

    Google Scholar 

  8. Zhang BJ, Wang CT, Wang YL. Protective effect of Shenfu Injection against myocardial ischemia and reperfusion injury in rats. Chin J Anesthesiol (Chin) 2005;25: 776–777.

    Google Scholar 

  9. Cao J, Min S. Protective effects of cardioplegic solution containing Shenfu Injection on isolated rabbit heart against ischemia-reperfusion injury. Chin J Anesthesiol (Chin) 2006;26: 61–64.

    Google Scholar 

  10. Ke DZ, Chen QW, Li CHL, Li GQ. Study on cytokine mechanism of Shenfu Injection in treating dogs with cardiogenic shock. China J Chin Mater Med (Chin) 2007;32: 2273–2276.

    Google Scholar 

  11. Roubille F, Cayla G, Plcotm C, Pradet V, Massin F, Gervasoni R, et al. C-reactive protein (CRP) after revascularized STEMI: Is CRP a prognostic factor? Rev Med Intern 2008;29: 868–874.

    Article  CAS  Google Scholar 

  12. Shpektor A. Cardiogenic shock: the role of inflammation. Acute Card Care 2010;12: 115–118.

    Article  PubMed  Google Scholar 

  13. Picariello C, Lazzeri C, Chiostri M, Gensini GF, Valente S. Kinetic of procalcitonin in patients with cardiogenic shock following acute myocardial infarction: preliminary data. HSR Proceedings in Intensive Care and Cardiovascular Anesthesia 2010;2: 201–207.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Gu J, Hu W, Xiao H, Feng X, Chen Y, Zhang D. Intra-aortic balloon pump improves clinical prognosis and attenuates C-reactive protein level in acute STEMI complicated by cardiogenic shock. Cardiology 2010;117: 75–80.

    Article  CAS  PubMed  Google Scholar 

  15. Di Iorio A, Ferrucci L, Sparvieri E, Cherubini A, Volpato S, Corsi A, et al. Serum IL-1beta levels in health and disease: a population-based study. The InCHIANTI study. Cytokine 2003;22: 198–205.

    Article  PubMed  Google Scholar 

  16. Zhang JX, Cheng X, Liao YH, Lu B, Yang Y, Li B, et al. Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction. Cardiovasc Drugs Ther 2005;19: 13–21.

    Article  CAS  PubMed  Google Scholar 

  17. Thiele H, Zeymer U, Neumann FJ, Ferenc M, Olbrich HG, Hausleiter J, et al. Intra-aortic balloon support for myocardial infarction with cardiogenic shock. N Eng J Med 2012;367: 1287–1296.

    Article  CAS  Google Scholar 

  18. Chen MQ, Li WH, Shi GX. Research progress of pharmacological effects on the cardiovascular system of ginsenoside Rb. Med Recapit (Chin) 2015;21: 519–521.

    Google Scholar 

  19. Li R. Progress of Shenfu Injection in treating chronic heart failure. Chin J Integr Med Cardio/Cerebrov Dis (Chin) 2014;12: 1257–1260.

    Google Scholar 

  20. Tsounis D, Bouras G, Giannopoulos G, Papadimitriou C, Alexopoulos D, Deftereos S. Inflammation markers in essential hypertension. Med Chem 2014;10: 672–681.

    Article  CAS  PubMed  Google Scholar 

  21. Kim K, Lee JH, Chang HJ, Cho YS, Youn TJ, Chung WY, et al. Association between blood pressure variability and inflammatory marker in hypertensive patients. Circulation 2008;72: 293–298.

    Article  CAS  Google Scholar 

  22. Abramson JL, Lewis C, Murrah NV, Anderson GT, Vaccarino V. Relation of C-reactive protein and tumor necrosis factor-alpha to ambulatory blood pressure variability in healthy adults. Am J Cardiol 2006;98: 649–652.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China

    Yan-yan Jin, Hai Gao, Xin-yong Zhang, Hui Ai, Xiao-lin Zhu & Jing Wang

Authors
  1. Yan-yan Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hai Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xin-yong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hui Ai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiao-lin Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jing Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hai Gao.

Additional information

Supported by Beijing Chinese Medicine Technology Development Surfaces Subject of Special Funds (No. JJ2013-19)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jin, Yy., Gao, H., Zhang, Xy. et al. Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock. Chin. J. Integr. Med. 23, 170–175 (2017). https://doi.org/10.1007/s11655-016-2749-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11655-016-2749-x

Keywords

Search

Navigation