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Microenvironment of liver regeneration in liver cancer

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Abstract

The occurrence and development of liver cancer are essentially the most serious outcomes of uncontrolled liver regeneration. The progression of liver cancer is inevitably related to the abnormal microenvironment of liver regeneration. The deterioration observed in the microenvironment of liver regeneration is a necessary condition for the occurrence, development and metastasis of cancer. Therefore, the use of a technique to prevent and treat liver cancer via changes in the microenvironment of liver regeneration is a novel strategy. This strategy would be an effective way to delay, prevent or even reverse cancer occurrence, development and metastasis through an improvement in the liver regeneration microenvironment along with the integrated regulation of multiple components, targets, levels, channels and time sequences. In addition, the treatment of "tonifying Shen (Kidney) to regulate liver regeneration and repair by affecting stem cells and their microenvironment" can regulate "the dynamic imbalance between the normal liver regeneration and the abnormal liver regeneration"; this would improve the microenvironment of liver regeneration, which is also a mechanism by which liver cancer may be prevented or treated.

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Authors and Affiliations

  1. Institute of Application Foundation and Institute of Liver Diseases, Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, 430061, China

    Han-min Li & Zhi-hua Ye

  2. Hubei Province Academy of Traditional Chinese Medicine, Wuhan, 430074, China

    Han-min Li & Zhi-hua Ye

Authors
  1. Han-min Li
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  2. Zhi-hua Ye
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Correspondence to Han-min Li.

Additional information

Supported by the National Natural Science Foundation of China (No. 81373513), and Research Projects of Key Diseases of the National Traditional Chinese Medicine Clinical Research Center, Hubei Province (No. JDZX2012054, JDZX2015172)

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Li, Hm., Ye, Zh. Microenvironment of liver regeneration in liver cancer. Chin. J. Integr. Med. 23, 555–560 (2017). https://doi.org/10.1007/s11655-017-2806-0

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  • DOI: https://doi.org/10.1007/s11655-017-2806-0

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