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Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats

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Abstract

Objective

To evaluate the efficacy of Bawu Decoction (八物汤, BWD, Palmul-tang in Korean) against benign prostatic hyperplasia (BPH).

Methods

Twenty-four male Wistar rats were divided into 4 groups, with 6 rats in each group. The 4 study groups included sham-operated group (CON), BPH model group, fifinasteride-treated group, and BWD-treated group. All the groups except CON group received a subcutaneous injection of 10 mg/kg of testosterone, while CON group received saline. Finasteride at a dose of 5 mg/kg was administered to the finasteride-treated group for a period of 4 weeks. BWD group received BWD at a dose of 200 mg/kg for 4 weeks. The prostatic weight, prostate weight to body weight ratio, relative prostate weight ratio, serum testosterone and dihydrotestosterone (DHT) level, and histological analysis of prostatic tissue were analyzed.

Results

Compared to BPH model group, BWD administration was associated with reductions in prostatic weight, prostate and relative prostate weight ratio weight to body weight ratio (P<0.05). The concentration of serum testosterone and DHT were higher in BPH group compared with CON group (P<0.05). Administration of finasteride and BWD suppressed the elevation of serum testosterone and DHT levels signifificantly (both P<0.05). In addition, BWD suppressed the growth of prostatic tissue (P<0.05).

Conclusion

BWD has suppressant effects on development of BPH through inhibition of serum testosterone and DHT.

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Authors and Affiliations

  1. Department of Physiology, College of Korean Medicine, Sangji University, Wonju-si Gangwon-do, 220-702, Republic of Korea

    Ji-Hwan Eom & Myung-Dong Kim

  2. Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si Gangwon-do, 220-702, Republic of Korea

    Se-Yun Cheon, Kyung-Sook Chung & Hyo-Jin An

Authors
  1. Ji-Hwan Eom
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  2. Se-Yun Cheon
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  3. Kyung-Sook Chung
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  4. Myung-Dong Kim
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  5. Hyo-Jin An
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Corresponding author

Correspondence to Hyo-Jin An.

Additional information

Supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning(NRF- 2016R1C1B2011827)

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Eom, JH., Cheon, SY., Chung, KS. et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats. Chin. J. Integr. Med. 23, 611–616 (2017). https://doi.org/10.1007/s11655-016-2528-8

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  • DOI: https://doi.org/10.1007/s11655-016-2528-8

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