中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Jia-qing Zhang	Department of Endocrinology, Changhai Hospital, Second Military Medical University, 200433, Shanghai
Da-jin Zou	Department of Endocrinology, Changhai Hospital, Second Military Medical University, 200433, Shanghai

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Abstract:

The levels of estrogen receptor (ER) in human peripheral leucocytes in 22 women with climacteric syndrome were measured by radioligand method. The results were compared with those of 12 healthy women of child-bearing age. It was found that the contents of leucocytic ER in patients with climacteric syndrome were significantly lower than healthy women of child-bearing age (372±149 vs 1143 ±255 Rs binding sites/cell). The authors used a Chinese prescription — Liuwei Dihuang Pills (LDP) to treat the patients for 2 months. The levels of leucocytic ER were increased after treatment. The data indicate a decrease of ER levels in leucocytes may be involved in the pathogenesis of climacteric syndrome. LDP not only increase plasma estradiol levels, but also increase the leucocytic ER levels. This may be the basis of the therapeutic effect of LDP on climacteric syndrome.