中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Clinical observation of high dose cinobufocini in attenuation and treatment of infection and granulocytopenia during combined chemotherapy of malignant blood disease

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Author Name	Affiliation
Bei-bei Yue	The First People’s Hospital of Shashi, 434000, Hubei
Le-san Xia	The First People’s Hospital of Shashi, 434000, Hubei
Cheng-tai Yuan	The First People’s Hospital of Shashi, 434000, Hubei
Qing Wu	The First People’s Hospital of Shashi, 434000, Hubei
Ming-qing Xiang	The First People’s Hospital of Shashi, 434000, Hubei
Shao-kun Dong	The First People’s Hospital of Shashi, 434000, Hubei
Zheng-ju Zhou	The First People’s Hospital of Shashi, 434000, Hubei

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Abstract:

The use of high dose cinobufocini in attenuation and treatment of infection and granulocytopenia during combined chemotherapy was observed in patients with malignant blood diseases. The study was designed in such a way that each patient served also as part of the control group. The test group included 18 males and 12 females, ranged in ages between 16 and 66 (averaged 34). Sixty-two experiments were run on 20 patients with acute leukemia, 8 with malignant lymphoma and 2 with multiple myeloma. The test group was treated with high dosages of cinobufocini. In each case, instances of infection were significantly decreased and the number of granulocytes was not markedly changed by the treatment. The results of this study suggest that high dosage cinobufocini therapy may significantly reduce the risk of infection and the degree and duration of granulocytopenia associated with chemotherapy for malignant blood diseases. Also, high dosage cinobufocini therapy is simple, convenient and causes little or no side effects.