中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Ren-fu Xie	China-Japan Friendship Hospital, 100029, Beijing
Jun-xian Liao	China-Japan Friendship Hospital, 100029, Beijing
Rou Ma	China-Japan Friendship Hospital, 100029, Beijing

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Abstract:

Herbal Medicines used to tonify Kidney and ameliorate the marrow microenvironment were applied in the treatment of 50 patients of aplastic anemia. Stanazol was also used to some cases. Forty-one cases (82.0%) responded well. It is significantly better than the 56.5% response among those treated with stanazol alone. Experimentally, the herbal medicines appear to stimulate hemopoietic progenitor cell proliferation, improve the marrow microenvironment and repair marrow damage induced by cyclophosphamide in vivo. The hemopoietic promoting effect might be partly due to the desialation of the marrow stroma cells. The herbal medicines also exert a positive effect on immune system by increasing leukocyte phagocytic activity and elevating the interleukin-2 production. Moreover, the decrease of superoxide dismutase resulting from cyclophosphamide injection could be reversed by the use of the herbal medicines. In conclusion, to tonify the Kidney and ameliorate marrow microenvironment medicines produce broad biological results that are beneficial to the body. Supported by the National Natural Science Foundation of China