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| The preventive-therapeutic effects of reduqing (热毒清) on endotoxin-induced DIC in rabbits (Continued) protection of hepatocytic microsomes, maintenance of calcium homeostasis and reduction of oxygen free radicals |
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| KeyWord:Reduqing endotoxin microsome calcium homeostasis oxygen free radicals |
| Author Name | Affiliation | | Ming-zhen Li | Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University, 430030, Wuhan | | Wang-yun Ye | Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University, 430030, Wuhan | | Sheng-hao Tu | Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University, 430030, Wuhan | | An-ji Hou | Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University, 430030, Wuhan | | Ze-ming Deng | Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University, 430030, Wuhan | | Fu-er Lu | Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University, 430030, Wuhan | | Kai-fu Wang | Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University, 430030, Wuhan | | Bao-ying Lin | Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University, 430030, Wuhan |
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| Abstract: |
| Disseminated intravascular coagulation (DIC) model of rabbits was made by the injection of endotoxin. Cytochrome P-450 content and aniline hydroxylase activity in hepatocytic microsomes in DIC rabbits were significantly reduced. The microviscosity of mitochondrial membrane was elevated, while the fluidity of the membrane, and the activities of calcium-magnesium-adenosine triphosphatase and calcium-adenosine triphosphatase were reduced. Lipid peroxide and xanthine oxidase activities were increased, while superoxide dismutase and glutathione peroxidase activities were significantly decreased (P<0.05 or <0.01). The changes in the Reduqing test group were not prominent, and the parameters of the test group were close to those of the control group. This study suggests that in endotoxin induced DIC rabbits the hepatocytic microsomes are injured, calcium homeostasis is disturbed and oxygen free radicals are notably accumulated. Whereas Reduqing may have a protective effect on hepatocytic microsomes from the injury, maintain calcium homeostasis and reduce oxygen free radicals in DIC rabbits. |
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