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| Clinical study on epidural injected lappaconitine for post-operative analgesia |
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| KeyWord:Lappaconitine, morphine, epidural space, post-operative analgesia, |
| Author Name | Affiliation | | Min-Guang Chen | Affiliated People’s Hospital, Fujian College of TCM, 350004, Fuzhou | | Qi-Hao Wang | Affiliated People’s Hospital, Fujian College of TCM, 350004, Fuzhou | | Yu-Bing Lin | Affiliated People’s Hospital, Fujian College of TCM, 350004, Fuzhou | | Kong-Li Chen | Affiliated People’s Hospital, Fujian College of TCM, 350004, Fuzhou | | Hua-Yang Lin | Affiliated People’s Hospital, Fujian College of TCM, 350004, Fuzhou | | Wei Lin | Affiliated People’s Hospital, Fujian College of TCM, 350004, Fuzhou | | Qing Lin | Affiliated People’s Hospital, Fujian College of TCM, 350004, Fuzhou | | Fei Liu | Affiliated People’s Hospital, Fujian College of TCM, 350004, Fuzhou |
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| Abstract: |
| This paper studied the effect and side-effect of epidural injected Lappaconitine (LC) for post-operative analgesia. 50 patients who were operated in the upper abdomen with epidural anesthesia, wererandomly divided into 5 groups. The general condition of each group was similar. Group A, B , C was given LC4mg, 8mg, 12mg respectively for observation. Group D, E was given 0.9% NS 6ml and morphine 2mg indi-vidually as control. When the operation was finished, LC was injected into the epidural space with singleblind method. The result showed the analgesia of LC and its effective time was: group E >C > B >A > D . Theanalgesic effect of group C was satistactory. The efficacy and the maintenance time of A, B, C groups weresignificantly different from that of group D ( P < 0. 05 , P < 0 . 01 ) . Although the effect ot group C was less po-tent than that of group E ( morphine injection) , there was no side-effect like that of morphine. It suggestedthat epidural injected LC for post-operative analgesia is effective and safe. |
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