中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Yao-Chun Liu	Weifang Medical College, 261042, Shandong
Gui-Ying Liu	Weifang Medical College, 261042, Shandong
Ru-Lin Liu	Weifang Medical College, 261042, Shandong
Xiu-Zhen Cheng	Weifang Medical College, 261042, Shandong
Ning Li	Weifang Medical College, 261042, Shandong
Jian-Ping Hou	Weifang Medical College, 261042, Shandong

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Abstract:

In order to prevent ototoxicity of kanamycin ( KM) , the effects of Poria Cocos (PC) on the o-totoxicity induced by KM in guinea-pigs was observed by giving the PC decoction to guinea-pigs with compar-ing the difference in the general intoxicating symptom, Prayer's retlex (PR) threshold, brainstem auditory e-voked potentials (BAEPs) and the absence rate of outer hair cells in the first turn of cochlea. The results sug-gested that the ototoxicity od KM was retarded by PC decoction. On the 7th day after KM was given, PRthreshold of 4, 6, 8 kHz in the medicated group and control group were 4. 7 1 . 5 dB, 5. 7 2. 4 dB, 2. 7 1 . 2 dB and 10. 5 3 . 2 dB, 12 . 1 3 . 7 dB, 8. 5 2 . 7 dB respectively. BAEPs threshold on the 13th day afterKM was given, raised 22 . 7 9 . 7 dB in the PC group and 51 . 3 14. 4 dB in the control group. The absencerate of outer hair cells in the first turn of cochlea were 39 . 4% and 67 . 4% respectively. The results suggestedthat PC might be antagonistic to the ototoxicity of KM in guinea-pigs.