中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Jin Wu	Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing
Yu-Qi Liu	Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing
Ke-Ji Chen	Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing

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Abstract:

The effect of herbal medicine preparation Composite Donyuan Gao (CDYG) on the animal model of drug dependence was studied. After the morphinistic models of white rats and mice had been made by closes of morphine which were ever increased daily and each time, the animals were divided into large dose CDYG group, small dose CDYG group, sustained morphine group and the control group. The withdrawal symptoms were observed after naloxone was given to the animal intraperitoneally. The results showed that in the CDYG groups withdrawal symptoms of the addicted white rats were alleviated, the number of jumps of the addicted mice was reduced, the scores of the principal symptoms of the animals were decreased, while the animals gained soon in weight. Comparing with the control group, the difference was significant (P<0.01). The fact that the effect of the CDYG was enhanced in the large dose group, suggests that it was dosage dependent.