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| Clinical and experimental study on treatment of acute respiratory tract infection with Shuanghuanglian Aerosol |
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| Author Name | Affiliation | | Yue-Hong Wang | Second Affiliated Hospital of Harbin Medical University, 150086, Harbin | | Kai-Jian Xu | Second Affiliated Hospital of Harbin Medical University, 150086, Harbin | | Wei-Shi Jiang | Second Affiliated Hospital of Harbin Medical University, 150086, Harbin | | Fu-Zhen Lu | Second Affiliated Hospital of Harbin Medical University, 150086, Harbin | | Meng-Ying Hu | Second Affiliated Hospital of Harbin Medical University, 150086, Harbin | | Zeng-Ke Zhe | Second Affiliated Hospital of Harbin Medical University, 150086, Harbin | | Feng Gao | Second Affiliated Hospital of Harbin Medical University, 150086, Harbin | | Jing-Wei Zhang | Second Affiliated Hospital of Harbin Medical University, 150086, Harbin | | Xiao-Lian He | Harbin Municipal Children’s Hospital, Harbin | | Feng-Yang Hong | First Affiliated Hospital of Harbin Medical University, Harbin |
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| Abstract: |
| Two hundred and two cases of acute respiratory tract infection (ARI) were treated with Shuanghuanglian (SHL) aerosol. In these cases, the majority were virus infection and 64% of them was caused by the respiratory syncytial virus (RSV). The virostatic and bacteriostatic test were done in vitro by the cell culture method and it was shown that SHL could inhibit the RSV, para-influenza virus I ~ IV and 23 kinds of pathogenic bacteria such as Staphylococcus aureus etc. The bacteriostatic effect was positively correlated to the SHL concentration. Experimental study showed that SHL could enhance the NK cell activity, promote the production of α-interferon and raise the rate of lymphocyte transformation. The controlled observation on SHL preparation with various dosage-forms revealed that the SHL aerosol in treating early ARI showed better results than that of injections and oral liquid symptomatologically (P<0.05). The total effective rate was 96%. |
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