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| Clinical and experimental study of RA mixture in treatment of rheumatoid arthritis |
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| Author Name | Affiliation | | De-Sheng Xu | Research Laboratory of Visceral Manifestation, Huashan Hospital, Shanghai Medical University, 200040, Shanghai | | Zi-Yin Shen | Research Laboratory of Visceral Manifestation, Huashan Hospital, Shanghai Medical University, 200040, Shanghai | | Wei Lu | Research Laboratory of Visceral Manifestation, Huashan Hospital, Shanghai Medical University, 200040, Shanghai | | Wen-Jian Wang | Research Laboratory of Visceral Manifestation, Huashan Hospital, Shanghai Medical University, 200040, Shanghai | | Ding-Fang Cai | Research Laboratory of Visceral Manifestation, Huashan Hospital, Shanghai Medical University, 200040, Shanghai | | Wei-Hua Chen | Research Laboratory of Visceral Manifestation, Huashan Hospital, Shanghai Medical University, 200040, Shanghai |
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| Abstract: |
| The RA mixture is composed of Tripterygium wilfordii (TW) and other Chinese medicinal herbs with effect of expelling Wind, activating blood circulation, invigorating the Kidney and Qi. The authors treated rheumatoid arthritis (RA) patients with RA mixture and compared it with D-Penicillamine as ocntrol. The two group’s therapeutical effect is similar (P >0.05), but side effect occuring ratio in treatment group was obviously lower than that of control group (P <0.01). After treatment with RA mixture, the patient’s human lymphocytic antigen-degenerative reaction (HLA-DR+) cell, CD4/CD8 ratio were reduced and automixed lymphocytic reaction (AMLR) level enhanced (P <0.05). The results of animal experiment showed that swelling of rheumatoid arthritis model mouse’s joint could be reduced by both RA mixture and TW. Comparing with TW, RA mixture had stronger effect in controlling the inflammation of synovial cell and fibroid degeneration of fibrocytes. At the same time, RA mixture had stronger effect in protecting immune organ from atrophy and maintaining functions of cellular immunity. All these suggest that RA mixture can reduce the syndroms of RA by improving distribution of T lymphocyte subsets and functions of cellular immunity. The Chinese medicinal herbs for reinforcing Kidney, supplementing Qi, activating blood circulation and expelling evil wind in the RA mixture could enhance TW’s therapeutical effect and reduce it’s side effect. |
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