中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes

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Author Name	Affiliation
Jie Feng	Department of Dermatology, The Second Affiliated Hospital, Xi’an Medical University, 710004, Xi’an
Han-Qing Xu	Department of Dermatology, The Second Affiliated Hospital, Xi’an Medical University, 710004, Xi’an
Bao-Shan Su	Department of Dermatology, The Second Affiliated Hospital, Xi’an Medical University, 710004, Xi’an

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Abstract:

In this immunohistochemical study, the authors detected the expression of c-myc in keratinocytes (ECK) from 30 psoriatics before and after Qingdai Compound Capsule (QDCC) treatment and 12 normal subjects for control. The results showed that the ECK of patients before treatment was significantly higher than that in the normal control group, and its level was correlated with histopathological changes of affected skin. After treatment the ECK was normalized. It is believed that QDCC could decrease the ECK in psoriatics and this effect was probably mediated by inhibiting c-myc expression. This study provided an experimental evidence for the application of QDCC in treating psoriasis.