中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis

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Author Name	Affiliation
Ke-Ying Zhou	Department of Pediatrics, Xiangya Hospital, Hunan Medical University, 410008, Changsha
Rong Huang	Department of Pediatrics, Xiangya Hospital, Hunan Medical University, 410008, Changsha
Pei-Lan Yu	Department of Pediatrics, Xiangya Hospital, Hunan Medical University, 410008, Changsha
Bao-Lin Zhang	Department of Pediatrics, Xiangya Hospital, Hunan Medical University, 410008, Changsha
Yu-Jia Yang	Department of Pediatrics, Xiangya Hospital, Hunan Medical University, 410008, Changsha
Pei-Fang Zhou	Department of Pediatrics, Xiangya Hospital, Hunan Medical University, 410008, Changsha
Yi-Xin Liu	Department of Pediatrics, Hospital of Overseas Chinese Town, Shenzhen

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Abstract:

This study aimed to evaluate the effect of tetramethylpyrazine in treating bacterial meningitis. Experimental model of rabbit meningitis was induced by intracisternal inoculation of 2 x 10⁷ colony-forming units of Escherichia Coli and tumor necrosis factor-α, thromboxane B₂ and 6-keto-prostagladin F_1α concentrations in cerebrospinal fluid of rabbits in different treatment groups were measured at 24 hrs, 27 hrs and 30 hrs after infection. Results showed that tetramethylpyrazine could significantly lower the concentrations of tumor necrosis factor-α and thromboxane B₂ in cerebrospinal fluid. Administration of both tetramethylpyrazine and ampicillin could attenuate the antibiotic-induced rapid release of the 2 inflammatory mediators.