中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Qun Chen	Teaching and Research Section of Microbiology, Guangdong Medical College, 524023, Zhanjiang
Nan-Ju Chen	Teaching and Research Section of Microbiology, Guangdong Medical College, 524023, Zhanjiang
Sheng-Chun Wang	Teaching and Research Section of Microbiology, Guangdong Medical College, 524023, Zhanjiang

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Abstract:

The R plasmid curing experiment was performed in vitro with E. coli strain E. 102 bearing Rplasmid with multiple drug resistance as target bacteria and Rhizoma Coptidis as elimination agent, and theinfluence at different acting time of it on R plasmid elimination was also observed. Results showed that whenthe acting time was 24 hours, the cure rate of R plasmid was 2 . 42 % and when the action time increased to 48hours, the cure rate was elevated to 22. 57% . The missing pattern s of R plasmid might occur in diap-pearence of either multiple or single resistance.