中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Home

Chinese Version

Online office

Journal Online

Forthcoming Articles

Current Issue

Next Issue

Earlier Issues

Download

Editorial Board [2019/7/26]

Instructions for Authors [2015/1/26]

Instructions to Contributors [2013/3/25]

Top

Top Downloaded
Top Cited

Links

alljournals

扫描微信二维码，获取更多信息

Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action

View Full Text View/Add Comment Download reader

KeyWord:

Author Name	Affiliation
Li-Xin Chen	Departent of Emergency, Beijing
Jia-Zhen Liao	Department of Cardiology Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, 100700, Beijing
Wei-Qin Guo	Department of Cardiology Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, 100700, Beijing
Wei-Jie Yu	Department of Cardiology Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, 100700, Beijing
La-Mei Qin	Department of Cardiology Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, 100700, Beijing

Hits: 1007

Download times: 982

Abstract:

Dynamic observations for 4 weeks were made on left ventricular function and oxygen free radicals (OFR) in 43 patients who suffered the first attack of acute myocardial infarction and was hospitalized in Coronary Care Unit within 36 hours. The results showed that Radix Astragali (RA) could strenthen the left ventricular function and had an effect of scavenging OFR. After administration of RA, the ratio of pre-ejection period/left ventricular ejection time (PEP/LVET) was decreased, the superoxide dismutase (SOD) activities of erythrocytes were increased, and the lipid peroxidation (LPO) concentration of plasma was reduced. There was a significant difference between the RA group and the control group in the parameters mentioned above. The study demonstrated that the PEP/LVET ratio was closely correlated with SOD and LPO. It suggested that the scavenging effect of RA on OFR was one of its mechanisms of cardiotonic action.