中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Clinical study on Zhengan Xifeng () Decoction in preventing and treating hypertensive nephropathy) Decoction in preventing and treating hypertensive nephropathy

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Author Name	Affiliation
Bo-Ke Zhang	Department of Nephrology, Xijing Hosptial, The 4th Military Medical University, 710032, Xi’an
Zheng-Hui Zhao	Department of Nephrology, Xijing Hosptial, The 4th Military Medical University, 710032, Xi’an
Han-Min Wang	Department of Nephrology, Xijing Hosptial, The 4th Military Medical University, 710032, Xi’an
Jun Zhu	Department of Nephrology, Xijing Hosptial, The 4th Military Medical University, 710032, Xi’an

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Abstract:

Seventeen cases of hypertensive nephropathy with azotemia (test group) treated with Zhengan Xifeng Decoction (ZGXFD) and a routine regimen of Western Medicine were observed. The result was compared with that of 15 cases treated with routine regimen alone (control.group). After 3 months of treatment, the blood pressure, sodium excretion, blood urea nitrogen and creatinine were all reduced, while creatinine clearance rate (CCr) and residual renal function index (RRFI) were improved significantly in both groups. Compared with the control group, the treatment on the test group showed a more prominent effect on lowering of diastolic blood pressure, elevating the hemoglobin, reducing the blood level of triglyceride and creatinine as well as improving on CCr and RRFI, suggesting the deterioration of residual renal function could be restrained by ZGXFD, through improving the disorder of lipid metabolism, osmolality gradient and creatinine kinetics.