中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Xian-Bo Wang	The First Affiliated Hospital of Xinxiang Medical College, 453100, Henan
Yan Sang	The First Affiliated Hospital of Xinxiang Medical College, 453100, Henan
Qing Han	The First Affiliated Hospital of Xinxiang Medical College, 453100, Henan
Bao-Rui Guo	The First Affiliated Hospital of Xinxiang Medical College, 453100, Henan
Xi-Xin Liu	The First Affiliated Hospital of Xinxiang Medical College, 453100, Henan

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Abstract:

Objective: To study the effects of Chinese herbal medicine Tangshenkang (TSK) capsule on diabetic nephropathy (DN).Method: Fifty-seven patients with DN were randomly divided into two groups, the TSK-treated group and the control group-Results: Serious disorders of metabolism showed in DN patients, displayed high levels of thromboxane B₂/6-keto-prostaglandin F_1α(TXB2/6-keto-PGF_lα) ratio and lipid peroxide (LPO) as compared with those of healthy persons. After 6 weeks treatment with TSK, the urinary albumin level reduced obviously (by 51%), renal plasma flow (RPF) increased, glomerular filtration rate and LPO levels decreased. A positive correlation was observed between albuminuria level and TXB2/6-keto-PGF_lα ratio. The clearance rate of creatinine didn’t improve significantly. In the control group, no significant difference in the above-mentioned parameters between pre-treatment and post-treatment was found.Conclusion: TSK capsule possessed a significant effect in improving urinary albumin and glomerular function. These effects might be due to the property of TSK in adjusting TXB2/6-keto-PGF_lα ratio and its lipid-peroxidation in DN patients.