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| Effect of Reduqing on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits) on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits |
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| Author Name | Affiliation | | Ming-Zhen Li | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Wang-Yun Ye | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Ming Luo | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Chao-Dong Wu | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Guang Yang | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Kai-Fu Wang | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Bao-Ying Lin | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Yan-Ping Zhang | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Li-Jun Xu | Institute of Integration of Traditional and Western Medicine, Tongji Medical University, 430030, Wuhan | | Zi-Jian Wen | Searle-Monsanto Co., AAAE, 700 Chesterfield Parkway, 63198, Chesterfield, MO, USA |
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| Abstract: |
| Objective: To study the mechanism of anti-endotoxemic effect of Reduqing Injection (RDQ) and to explore the essence of traditional Chinese “heat-clearing and detoxifying therapy”.Methods: A disseminated intravascular coagulation (DIC) model was made in rabbits by intravenous injection with E. coli endotoxin. Increased plasma levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8) and platelet activating factor (PAF), as well as the ex-vivo LPS-induced interleukin-1 (IL-1) production in peripheral blood monocytes were observed in model (M) group.Results: Same parameters were significantly lower in RDQ and dexamethasone (DXM) groups than those in the M group (P<0.01,P<0.05). Histopathological examination showed severe damage of the liver, lungs and kidneys in the rabbits of M group, in contrast, only mild affects were seen in the RDQ and DXM groups.Conclusions: RDQ exhibits protective effect on rabbits against endotoxin-induced DIC. The suppression of cytokines and inflammatory mediator PAF by RDQ may play a central role in the inhibition of endotoxin-induced DIC cascade. |
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