中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Shao-Jie Yue	Department of Pediatrics, Xiang Ya Hospital, Hunan Medical University, 410078, Changsha
Pei-Lan Yu	Department of Pediatrics, Xiang Ya Hospital, Hunan Medical University, 410078, Changsha
Yu-Jia Yang	Department of Pediatrics, Xiang Ya Hospital, Hunan Medical University, 410078, Changsha
Zi-Qiang Luo	Department of Physiology, Hunan Medical University, 410008, Changsha

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Abstract:

Objective: To observe the effect of 654-2 on brain edema model induced by pertussis bacilli in rabbits.Methods: Brain edema model of 26 rabbits induced by pertussis bacilli was prepared for observation, their brain water content and brain glutamate level were determined before and after treatment.Results: 654-2 could decline the water content of brain and increase the glutamate level in brain tissue of the treatment group as compared with group without treatment.Conclusion: 654-2 has protective effect on brain edema induced by pertussis bacilli.