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| Clinical study on Shuxuening combined with antipsychotics in treating chronic schizophreniacombined with antipsychotics in treating chronic schizophrenia |
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| Author Name | Affiliation | | He-chun Luo | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Yu-cun Shen | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Xin Yu | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Ping Liu | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Chun-xiang Tan | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Yu-hua Cui | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Fan-qiang Meng | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Xu-dong Yang | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Jian-cheng Liu | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Xue-ying Zhao | Mental Health Institute, Beijing Medical University, 100083, Beijing | | Hong-Wen Zhong | Mental Health Institute, Beijing Medical University, 100083, Beijing
Longquanshan Hospital, Guangxi | | Lian-Cheng Zhu | Mental Health Institute, Beijing Medical University, 100083, Beijing
Ankang Hospital, Beijing | | Mei-Lan Zhu | Mental Health Institute, Beijing Medical University, 100083, Beijing
Minkang Hospital, Beijing |
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| Abstract: |
| Objective: To make a preliminary evaluation of the clinical efficacy of Shuxuening (SXN).Methods: One hundred and forty-nine chronic schizophrenic patients were divided randomly into the SXN group and the control group in a double-blind research. SXN was given to the SXN group and placebo to the control group, and patients of both groups went on receiving the previous antipsychotic treatment. Brief Psychiatric Rating Scale (BPRS), Scale for Assessment of Negative Symptoms (SANS) and Treatment Emergent Symptoms Scale (TESS) were used to assess the effects of treatment and side effects of the drug. The evaluation was done before and during the 2nd, 4th, 6th, 10th and 12 th weeks in the course of treatment.Results: SXN was effective by BPRS evaluation (P < 0.05), and even the more effective to negative symptoms than positive symptoms by SANS evaluation (P < 0.05). It was safe and with little side effect. In addition, it was found that the incipience of SXN’ s efficacy was somehow related with the course of disease and the daily dosage used.Conclusion: SXN is worthy of further study n the treatment of chronic schizophrenia. |
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