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| Effect of Semen Persicae extract combined with cultured Cordyceps on reversing Capillarization of Sinusoids in patients with hepato-cirrhosis |
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| KeyWord:Semen Persicae, Cordyceps sinensis, amygdalin, hepato-cirrhosis, capillarization of sinusoids |
| Author Name | Affiliation | | Lie-Ming Xu | Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai | | Jian-Liang Zhu | Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai | | Cheng Liu | Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai | | Ping Liu | Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai | | Gang Lu | Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai | | Hui-Ming Xue | Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai | | Yi-Yang Hu | Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai | | Jia-He Hong | Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai |
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| Abstract: |
| Objective: To evaluate the effect of Semen Persicae combined with cultured Cordyceps on Reversing Capillarization of Sinusoids in patients with hepato-cirrhosis. Methods: Forty-four patients were treated for 3 months, the clinical and pathological effects were observed. Results: Patients were improved clinically.Pathological examination on liver biopsy of 6 patients also showed improvement in of capillarization of sinusoid,which mainly manifested by reduction of enlarged interhepatocellular spaces and collagen fiber in it, increase of lipid droplets within fat-storing cells (FSC), and decrease of proliferation of Kupffer cells. Conclusion: The combined treatment used could reverse the capillarization of sinusoid, and the mechanism might be related with its inhibition on activity and function of FSC. |
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