中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Effect of Xueguantong on plasma endothelin and calcitonin gene-related peptide in quail atherosis modelon plasma endothelin and calcitonin gene-related peptide in quail atherosis model

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Author Name	Affiliation
Ya-Wei Zhou	Xiyuan Hospital, China Acadeimy of Traditional Chinese Medicine, 100091, Beijing
Min Wang	Xiyuan Hospital, China Acadeimy of Traditional Chinese Medicine, 100091, Beijing
Zheng-Yan Ge	Xiyuan Hospital, China Acadeimy of Traditional Chinese Medicine, 100091, Beijing
Cheng-Ren Lin	Xiyuan Hospital, China Acadeimy of Traditional Chinese Medicine, 100091, Beijing
Ke-Ji Chen	Xiyuan Hospital, China Acadeimy of Traditional Chinese Medicine, 100091, Beijing

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Abstract:

Objective: To explore the antiatherogenic mechanism of the action of Xueguantong at molecular level.Methods: After being established by feeding with high fat diet for 12 weeks, the quail atherosis models were given Xueguantong for 30 days. Then, their plasma endothelin and calcitonin gene-related peptide (CGRP) were determined with radioimmunoassay (RIA) and the effects of Xueguantong on plasma endothelin and CGRP in the models were observed.Results: The plasma endothelin increased and CGRP decreased during quail atherosis formation. The plasma endothelin was decreased (P < 0.05) and CGRP increased (P < 0.05) by Xueguantong.Conclusion: One of antiatherogenic mechanisms of Xueguantong was decreasing endothelin and increasing CGRP.