中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Xue-Zhi Zhao	Department of Nephrology, Changzheng Hospital, 200003, Shanghai
Lei-shi Li	The General Hospital of Nanjing Military District, 210002, Nanjing

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Abstract:

Objective: To explore the protective effect ofCordyceps sinensis (CS) on nephrotoxicity of cyclosporine A (CsA) and its mechanism.Methods: The renal function of isolated perfused rats was observed before and after three months treatment by CS.Results: CS could improve the renal function, increase the volume of urine, Na⁺ and K⁺ excretion and inulin clearance rate, and reduce the resistance of renal perfusion. It was found that the activities of urinary N-acetyl-β-glucosaminidase (NAG), γ-glutamyl transferase (γ-GT) and lactate dehydrogenase (LDH) were lower in the CS treatment group than those in the control group.Conclusion: CS could protect the kidney from damage against nephrotoxicity of CsA and improve the abnormality of renal hemodynamics.