中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure

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Author Name	Affiliation
Duan Shaobin	The Second Affiliated Hospital of Hunan Medical University, 410011, Changsha
Luo Ji’an	The Second Affiliated Hospital of Hunan Medical University, 410011, Changsha
Liu Ruihong	The Second Affiliated Hospital of Hunan Medical University, 410011, Changsha
Xu Xiping	Department of Electron Microscope, Hunan Medical University, Changsha

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Abstract:

Objective: Radiographic contrast media can induce renal failure and it may serve as an experimental model of acute renal failure (ARF). The study was aimed to determine the protective effect of Shengmai Injection (SMI) on contrast medium-associated ARF in Sprague-Dawley (SD) rats.Methods: Twenty healthy SD rats of both sex were randomly divided into two groups, Group A (control group) treated with glycerin+0. 9% saline+meglucamine diatrizoate, and group B (preventive group) with glycerin+SMI+meglucamine diatrizoate.Results: In Group B, the levels of blood urea nitrogen, serum creatinine, renal phospholipase A₂ (PLA₂) and calcium were all significantly lower than those in Group A,P < 0.01. The results indicated the renal injury induced by meglucamine diatrizoate was alleviated by SMI.Conclusion: SMI could prevent renal tissue from contrast media induced nephropathy in SD rats. The effect may partially owe to its preventing intracellular calcium accumulation, inhibiting PLA₂ activity and dilating renal vessels.