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| Treatment of Liver fibrosis of hepatitis B by interferon-α1 and traditional medicine preparationΔ |
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| Author Name | Affiliation | | Cheng Mingliang | Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang | | Wu Yayun | Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang | | Huang Kefu | Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang | | Luo Tianyong | Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang | | Ding Yisheng | Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang | | Lu Yinying | Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang | | Liu Rencai | Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang | | Wu Jun | Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang |
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| Abstract: |
| Objective: To find the effective method of curing liver fibrosis of hepatitis B.Methods: Using interferon-α1 (IFN-α1) and traditional Chinese medicine (TCM) preparation to treat the patients with liver fibrosis of hepatitis B and observe the changes of indexes including levels of laminin, precollagen type III, hyaluronic acid, liver puncture, ultrasonography and fibergastroscopy before and after treatment.Results: After 3 months treatment, the indexes were lower than those before treatment. There was a significant difference (P < 0.01). Liver biopsy, ultrasonography and fiber-gastroscopy proved that the liver fibrosis was improved. After 6 months the indexes of the hepatofibrosis, blood albumin and globulin levels showed that the differences between the IFN-effective group and the IFN-ineffective group was significant (P < 0.001).Conclusion: Beneficial effect might be obtained by using IFN-cq to suppress the replication of hepatitis B virus and TCM preparation to treat liver fibrosis. |
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