中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Zhang Kejian	Beijing Hospital, National Center for Clinical Laboratories, 100730, Beijing
Liu Gengtao	Institute of Materia Medica, Chinese Academy of Medical Sciences, 100730, Beijing

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Abstract:

Objective: To explore the effect of total saponins of Ginseng leaves(GS) on the functions ofneutrophil and lymphocyte in the aged rats of 20 months. Methods: Three groups of aged rats were injected intraperiton-eally with doses of 12. 5 mg/kg, 25 kg/mg and 50 mg/kg of GS once daily for 3 days, the declinedimmunity of spleen lymphocytes (proliferation of spleen lymphocyte, phagocytosis), superoxide anion and nitricoxide formation were studied and were compared with those of young rats (2 months). Results: The declinedimmunity of spleen lymphocytes were improved dose-dependently after GS injected. Conclusion: The results indicate that GS may enhance neutrophil and lymphocyte mediated non--specific and specific defense function inaged rats.