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| Clinical and experimental study on Fuzheng Baozhen Decoction () in enhancing effect of radio- and chemotherapy for malignant tumors) in enhancing effect of radio- and chemotherapy for malignant tumors |
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| Author Name | Affiliation | | Li Jing | Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, 410078, Changsha | | Li Xinqun | Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, 410078, Changsha | | Li Jiabang | Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, 410078, Changsha | | Liang Qinghua | Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, 410078, Changsha | | Xiang Yueqian | Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, 410078, Changsha | | Yuan Jun | Xiangya Hospital, Hunan Medical University, Changsha | | Tang Lili | Xiangya Hospital, Hunan Medical University, Changsha |
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| Abstract: |
| Objective: To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio- and chemotherapy for malignant tumors. Methods: One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and radiotherapy. Among them 55 cases were treated together with FZBZD (group A), 30 cases together with Zhenqi Fuzheng Granules (group B), and the other 32 cases treated with radio- and chemotherapy alone (group C). Mechanism of FZBZD enhancing effect of chemotherapy in treating transplanted human lung adenocarcinoma (SPC-A-1) and sarcoma (S180) bearing mice was conducted experimentally. Results: Effective rates (CR+PR) of group A, B and C were 63.6%, 43.3% and 37.5% respectively, that of group A being the best (P < 0.05). The survival quality of life was improved the most in group A (P < 0.05). The picture of peripheral blood (WBC, Hb, PLT count) of group A after treatment was better than that of the other two groups (P < 0.05). And CD3, CD4, NK activity, interleukin-2 levels were also improved more significantly in group A (P < 0.01) than those in the other two. Animal experiment showed that FZBZD could improve the effect of chemotherapy in inhibiting tumor growth (P < 0.01), raising cAMP/cGMP ratio (P < 0. 01) by increasing the cAMP level in cancer tissue, and enhancing cells ofG0/G1 phase and reducing cells of S phase. Conclusion: FZBZD inhibited tumor growth and enhanced the effect of radio- and chemotherapy by improving immune and hematopoietic function, cAMP/cGMP ratio and halting tumor cells in G0/G1 phase. |
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