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Effect of theo-polyphenols () on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats |
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Author Name | Affiliation | Ke Yongsheng | Yijishan Hospital, Wannan Medical College, Wuhu, 241001, Anhui | Liu Zhaofang | Yijishan Hospital, Wannan Medical College, Wuhu, 241001, Anhui | Zhao Zhendong | Yijishan Hospital, Wannan Medical College, Wuhu, 241001, Anhui |
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Abstract: |
Objective: To observe the effect of theo-polyphenols (TP) on function of trans-membranous signal of acute ischemic myocardium in rats.Methods: Model of myocardial ischemia was established. Thirtyfive male rats were randomly divided into 5 groups, 7 rats in each group. Non-ischemic group: the anterior descending branch of left coronary artery was not ligated; Ischemic group: the time of ischemia continued for 10 min; TP groups: the groups were divided into 3 subgroups, TP dose was respectively 1 mg/kg, 4 mg/kg, 16 mg/kg, TP was administered through celiac injection 20 min before the anterior descending branch of left coronary artery was ligated.Results: The levels of phosphatidylinositol-4, 5-biphosphate (PIP2), inositol-1, 4, 5-triphosphate (IP3) in the ischemic group were markedly higher than those in the non-ischemic group. The raise of the levels of PIP2, IP3 caused by acute myocardial ischemia were markedly inhibited by the TP. The relationship of dose-effect was observed.Conclusion: TP has inhibitory effect of trans-membranous signal system of acute ischemic myocardium. It has protective effect on myocardium. |
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