中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Wang Xiaofang	The Cardiovascular Department of Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing
Liu Jiangang	The Cardiovascular Department of Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing
Shi Dazhuo	The Cardiovascular Department of Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing
Bao Xiaofeng	The Cardiovascular Department of Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing

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Abstract:

Objective: To observe the effects of Xin’an capsule (XAC) on experimental ventricular arrhythmia (EVA) in animals and to explore the possible mechanism.Methods: Three types of animal arrhythmic model (ventricular arrythmia in guinea pigs induced by Ouabin, in rats caused by reperfusion after ligation of descending anterior branch of coronary artery and by CaCl₂) were used to study the effects of XAC on ventricular arrhythmia (VA).Results: After XAC treatment, the dosage of Ouabin needed for inducing ventricular premature beat (VPB), ventricular tachycardia (VT) and ventricular fibrillation (VF) increased in guinea pigs. The sustaining time of reperfusion induced VT and total occurrence of ventricular arrhythmias decreased. XAC also showed an effect in increasing CaCl₂ dosage needed to cause VA, and decreased the occurrence of VF and death in rats