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Influence of Buyang Huanwu Decoction on activity of blood platelet activating factor receptor in rabbit) on activity of blood platelet activating factor receptor in rabbit
  
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Zhang Jiping Pharmacology Department, College of Pharmacy, Beijing Medical University, Beijing 
Li Changling Pharmacology Department, College of Pharmacy, Beijing Medical University, Beijing 
Guo Xinxin Pharmacology Department, College of Pharmacy, Beijing Medical University, Beijing 
Wang Yinye Pharmacology Department, College of Pharmacy, Beijing Medical University, Beijing 
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Abstract:
      Objective: To observe the influence of Buyang Huanwu Decoction (BYHWD) on the activity of blood platelet activating factor receptor (PAFR).Methods: BYHWD was administered to rabbits in vitro or in vivo and its effect on PAFR was observed by radioligand receptor binding method.Results: BYHWD tended to increase the specific binding amount of washed-platelet-PAFR with radioligand in vivo, which was similar to that of Ginkgo leaf extract. And in vitro, it showed an inhibition on the specific binding of washed-platelet-PAFR.Conclusion: BYHWD has certain effect on PAFR amount in vivo and PAFR activity in vitro
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