中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Zhaoshun Jiang	General Hospital of Jinan Military Region, 250031, Jinan
Shenglan Zhang	General Hospital of Jinan Military Region, 250031, Jinan
Tianqin Kou	Jining Hospital of Traditional Chinese Medicine, china
Wanjia Xing	General Hospital of Jinan Military Region, 250031, Jinan
Hui Yan	General Hospital of Jinan Military Region, 250031, Jinan
Geping Yin	General Hospital of Jinan Military Region, 250031, Jinan

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Abstract:

Objective: To study the relationship between blood stasis syndrome (BSS) and platelet activation and its influencing factors in type 2 diabetic mellitus (DM).Methods: Platelet CD_62p, CD₆₃ expressions were determined in 30 type 2 DM patients with BSS, 27 type 2 DM patients without BSS and 20 normal controls by flow cytometry.Results: CD_62p, CD₆₃ levels were significantly higher in type 2 DM group with BSS than those in the type 2 DM group without BSS and in the normal controls. CD_62p was positively correlated with CD₆₃, while positive correlation existed between HbA₁c, LDL-C and CD_62p in DM patients with BSS.Conclusions: The increased level of platelet activation was the primary molecular basis of BSS in type 2 DM. It was important to perform the syndrome differentiation of BSS and treatment of activating blood flow to remove BSS in type 2 DM.