中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Changquan Ling	Changhai Hospital. The Second Military Medical University, 200433, Shanghai
Min LI	The Public Sanitary Department of the Second Military Medical Univeristy, china
Jinxing Tan	Changhai Hospital. The Second Military Medical University, 200433, Shanghai
Junhua Lu	Changhai Hospital. The Second Military Medical University, 200433, Shanghai

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Abstract:

Objective: To probe the relationship of glucocorticoid receptor and some Chinese medicinal herbs.Methods: The model of Qi-Yang exhaustion and Qi-Yin exhaustion were made with hemorrhagic rats and heat-stressed rats respectively. The effect of Shenfu decoction (SFD) and Shengmai powder (SMP) on plasma glucocorticoid (GC) and its receptor (GcR) in hepatic cytosol of the models were measured respectively.Results: The activity of GcR decreased in both models, while their blood level of GC increased markedly. SFD and SMP showed no regulating effect on blood GC, but displayed obvious up-regulation on GcR level in both models.Conclusion: SFD and SMP could up-regulate the activity of GcR in Qi-Yang and Qi-Ying exhaustion models. This study was supported by National Natural Science Foundation (No. 30670882)