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| Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease |
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| Author Name | Affiliation | | Jiangbin Chen | Department of Cardiology, the First Affiliated Hospital, Hubei Medical University, 430060, Wuhan | | Jiali Xu | Department of Cardiology, the First Affiliated Hospital, Hubei Medical University, 430060, Wuhan | | Jianjun Li | Department of Cardiology, the First Affiliated Hospital, Hubei Medical University, 430060, Wuhan | | Congxin Huang | Department of Cardiology, the First Affiliated Hospital, Hubei Medical University, 430060, Wuhan | | Qizhu Tang | Department of Cardiology, the First Affiliated Hospital, Hubei Medical University, 430060, Wuhan | | Jinming Wang | Department of Cardiology, the First Affiliated Hospital, Hubei Medical University, 430060, Wuhan | | Gengshan Li | Department of Cardiology, the First Affiliated Hospital, Hubei Medical University, 430060, Wuhan |
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| Abstract: |
| Objective: To observe the effect of puerarin on superoxide dismutase (SOD), lipid peroxidation (LPO), tissue plasminogen (TPA) and plasminogen activator inhibitor (PAI-1) of coronary heart disease (CHD) patients.Methods: Forty-eight patients were divided into two groups (treated group and control group). Treated group was given intravenously 600 mg puerarin, once daily for one week, also the same treatment as that of control was given. Nitrite colorimetric method, radioimmunoassay (RIA), TBA fluorescent development process and fibrinolysin specific colorbase substrate decomposition development process were used to determine SOD activity, SOD, LPO, TPA and PAI-1.Results: After the treatment with puerarin, SOD activity was increased, LPO reduced, while without any changes in the control group. There was insignificant changes of SOD between the treated and the control groups. TPA and PAI-1 were increased significantly in the treated group, but was insignificantly changed in the control group.Conclusion: Puerarin can increase the SOD activity, decrease LPO level and enhance the activity of fibrinolysis. |
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