中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Home

Chinese Version

Online office

Journal Online

Forthcoming Articles

Current Issue

Next Issue

Earlier Issues

Download

Editorial Board [2019/7/26]

Instructions for Authors [2015/1/26]

Instructions to Contributors [2013/3/25]

Top

Top Downloaded
Top Cited

Links

alljournals

扫描微信二维码，获取更多信息

Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats

View Full Text View/Add Comment Download reader

KeyWord:Tiangui Recipe androgen-sterilized rat leptin pituitary gonadotropin

Author Name	Affiliation
Fei Sun	Obstetric and Gynecologic Hospital, Shanghai Medical University, (200011), Shanghai
Jin Yu	Obstetric and Gynecologic Hospital, Shanghai Medical University, (200011), Shanghai

Hits: 1091

Download times: 558

Abstract:

Objective: To explore the effect of Tiangui Recipe (TGR) on obesity and reproductive function in androgen-sterilized rats (ASR).Methods: ASR model was established by subcutaneous injection of testosterone propionate to SD female rats at the age of 9 days. Change of serum leptin, follicular stimulating hormone (FSH) and luteinizing hormone (LH) in model rats aged 115 days before and after feeding them with TGR was measured by radioimmunoassay (RIA). Meanwhile, criteria of energy state, including diurnal food intake, retroperitoneal fat depot weight and body weight, were measured and evaluated.Results: ASR had the characteristics of high metabolic rate, energy imbalance and obesity. Serum level of leptin increased and FSH, LH decreased significantly (P<0.01) in model rats as compared with the normal rats. Significant positive correlation between leptin level and body weight (r=0.8977, P<0.001) was observed, and negative correlation was seen between FSH, LH and leptin (r = -0.7517, P<0.001; r= -0.8444, P<0.001, respectively). The endocrine changes of ASR all returned to normal range after the TGR treatment.Conclusion: Obesity and concerned hypogonadotrophic hypogonadal anovulation were expressed in ASR. TGR may play an important role in reducing weight and inducing ovulation.