中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Na Liu	Institute of Basic Medicine, Peking Union Medical College, 100005, Beijing
Pingping Zuo	Institute of Basic Medicine, Peking Union Medical College, 100005, Beijing
Fenghua Liu	Institute of Basic Medicine, Peking Union Medical College, 100005, Beijing
Hongyu Xue	Institute of Basic Medicine, Peking Union Medical College, 100005, Beijing

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Abstract:

Objective: To observe the behavioral and biochemical effects of a traditional Chinese medicine Huanshao Dan (HSD) on learning and memory deficits in transient cerebral ischemia model in mice.Methods: Step-through experiments, receptor binding test and choline acetyltransferase (ChAT) activities determination were performed.Results: Mice undertaken transient ischemia commited much more mistakes in step-through experiments and showed relatively higher³ H-MK801 binding in cerebral cortex and hippocampus than in sham operated animals. HSD decoction was most effective in reducing these mistakes in mice. At the same time, and³ H-MK801 binding of cerebral cortex and hippocampus tissues were also significantly decreased, while ChAT activities in the same tissues were increased.Conclusion: HSD might antagonize ischemic injury of brain through inhibition of glutamate N-methyl-D-Aspartic acid receptor overactivity. ΔThis program was supported by National Nature Science Foundation of China (No.39421012)