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| Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model |
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| KeyWord:Xiongshao capsule angioplasty restenosis vascular remodeling |
| Author Name | Affiliation | | Hao Xu | Division of Cardiovascular Diseases, Xiyuan Hospital, China Academy of TCM, 100091, Beijing | | Dazhuo Shi | Division of Cardiovascular Diseases, Xiyuan Hospital, China Academy of TCM, 100091, Beijing | | Keji Chen | Division of Cardiovascular Diseases, Xiyuan Hospital, China Academy of TCM, 100091, Beijing | | Xiaochang Ma | Division of Cardiovascular Diseases, Xiyuan Hospital, China Academy of TCM, 100091, Beijing | | Yongli Li | Department of Experimental Surgery, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences, China | | Liang Meng | Department of Experimental Surgery, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences, China | | Weimin Yuan | Department of Experimental Surgery, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences, China |
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| Abstract: |
| Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. They were divided into 5 groups, untreated or treated with probucol, Xueguantong, low and high dose of XSC respectively, and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared with the control group, all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 ), both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01 respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC could significantly inhibit the pathological vascular remodeling, and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery. Part of a National Ninth-Five Planning Project (No. 96-9060601) |
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