中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Guming Han	Xuzhou Geriatrics Institute, 221003, Jiangsu
Qian Yao	Xuzhou Geriatrics Institute, 221003, Jiangsu
Honlian Li	Xuzhou Geriatrics Institute, 221003, Jiangsu

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Abstract:

Objective: To explore the inhibitory pathway and the possible mechanism of panicoin on platelet activation.Methods: The effect of panicoin on platelet aggregation, thromboxane B₂ release, P-selectin (GMP-140) count, levels of cAMP and cGMP induced by ADP, epinephrine, arachidonic acid or thrombin were observed.Results: Panicoin could inhibit significantly platelet aggregation induced by ADP, arachidonic acid and epinephrine in a dose-dependent manner, thrombin induced GMP-140 on platelet surface and TXB₂ release, and increase the platelet cAMP level, but showed no effect on cGMP level.Conclusion: Panicoin shows a potent inhibition on platelet activation and antithrombotic effect. The mechanisms seems to be related with elevation of platelet cAMP.