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| Clinical effect of Xinqingning (新清宁) combined with low dose continuous gastrointestinal dialysis in treating uremia |
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| KeyWord:chronic renal failure, uremia, continuous gastrointestinal dialysis, rhubarb, mannitol |
| Author Name | Affiliation | | Yan-bing Sun | Department of Nephrology, Xuanwu Hospital, Capital University of Medical Sciences, 100053, Beijing | | Bing-liang Chen | Department of Nephrology, Xuanwu Hospital, Capital University of Medical Sciences, 100053, Beijing | | Qiang Jia | Department of Nephrology, Xuanwu Hospital, Capital University of Medical Sciences, 100053, Beijing | | Zheng Yao | Department of Nephrology, Xuanwu Hospital, Capital University of Medical Sciences, 100053, Beijing |
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| Abstract: |
| Objective: To investigate the clinical effect of Xinqingning (XQN), a preparation of rhubarb, combined with low dose continuous gastrointestinal dialysis in treating uremia. Methods: Patients of uremia were divided into three groups at random, 18 patients in group A were treated with 1000 ml gastrointestinal dialysate (non absorbed mannitol solution) orally 2-3 times a day, 20 patients in group B treated with the same therapy as that in group A, also combined with XQN 5-10 tablets 3 times per day and 19 patients in group C treated with orally taken coated aldehyde oxystarch 5-10 g, 3 times a day. The therapeutic course for the three groups was 11 months. The changes in clinical manifestation, renal function, nutritional condition, and electrolytes before and after treatment were observed. Results: After treatment, significant improvement was revealed in aspects of uremic symptoms, quality of life, nutritional condition, serum creatinine, urea nitrogen, serum phosphate, uric acid, CO 2 combining power, creatine clearance, body weight and arm muscular circumference in group A and B, as compared with those in group C. In comparison of group A with B, group B showed a lower serum triglyceride and a slower progression of chronic renal failure (CRF). All the criteria were not improved in group C and with serum creatinine being raised significantly. Conclusion: XQN combined with low dose continuous gastrointestinal dialysis therapy was definitely effective in treating uremia. It provides a new therapeutic means of non replacement therapy for CRF with uremia. |
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