|
| Effect of emodin on biological behavior of fibroblasts in lupus nephritis |
| |
| View Full Text View/Add Comment Download reader |
|
| KeyWord:emodin, fibroblast, proliferation, apoptosis, c myc protein |
| Author Name | Affiliation | E-mail | | Guan-xian Liu M. D. | Department of Nephrology, Huizhou Central People’s Hospital, No. 41 Eling North Road, 516001, Huizhou City, Guangdon Province | hzzxyy@21cn.com | | Ren-gao Ye | Institute of Nephrology, Sun Yat-sen University of Medical Science, People’s Republic of China | | | Zhi-ming Tan | Department of Nephrology, Huizhou Central People’s Hospital, No. 41 Eling North Road, 516001, Huizhou City, Guangdon Province | | | Wei-qiang Zhong | Department of Nephrology, Huizhou Central People’s Hospital, No. 41 Eling North Road, 516001, Huizhou City, Guangdon Province | | | Yong-ming Yang | Department of Nephrology, Huizhou Central People’s Hospital, No. 41 Eling North Road, 516001, Huizhou City, Guangdon Province | | | Guo-qiang Zhang | Institute of Nephrology, Sun Yat-sen University of Medical Science, People’s Republic of China | | | Jing-ai Fang | The First Affiliated Hospital, Shanxi Medical University, People’s Republic of China | |
|
| Hits: 1147 |
| Download times: 544 |
| Abstract: |
| Objective: To observe the effect of emodin on the biological behavior of human fibroblasts (FB) in culture of kidney in patients with lupus nephritis (LN). Methods: FB were isolated from kidney culture of LN patients, and the effect of emodin on 3H TdR incorporated rate of FB was observed. The apoptosis and c myc gene expression were detected in the same way by flow cytometry. Results: Emodin could markedly inhibit the proliferation of human kidney FB, and inducing cell apoptosis through up regulating c myc gene expression in human renal FB. Conclusion: Emodin can inhibit proliferation and promote apoptosis of FB, which may be important in ameliorating interstitial fibrosis, and thus improve prognosis of LN. |
| Close |
|
|
|
