中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Jian Chen	Department of Pediatrics, Zhejiang TCM Hospital, 310006, Hangzhou
Yu-yan Chen	Department of Pediatrics, Zhejiang TCM Hospital, 310006, Hangzhou
Xiao-ming Wang	Department of Pediatrics, Zhejiang TCM Hospital, 310006, Hangzhou
Gui-qi Xuan	Department of Pediatrics, Zhejiang TCM Hospital, 310006, Hangzhou

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Abstract:

Objective

To explore the effect of Jiangqian granule (JQG) in treating children attention deficit hyperactivity disorder (ADHD) and its mechanism.

Methods

Eighty children with ADHD were randomly divided into two groups, the treated group treated with JQG and the control group treated with Ritalin. Blood lead concentration and Conners scoring were measured before and after 3 months treatment and the therapeutic effects were assessed. Besides, blood lead concentration and Conners scoring in 60 healthy children were also determined for control.

Results

The total effective rate in the treated group and the control group was 92.5% and 72.5% respectively, significant difference existed between the two groups. Blood lead level and Conners scores in ADHD patients were significantly higher than those in the healthy control (P<0.01). The two parameters decreased after treatment in both groups, but the lowering was more significant in the treated group (P<0.05,P <0.01).

Conclusion

Blood lead concentration raised in ADHD patients, JQG could enhance the clinical therapeutic effect by means of reducing the blood lead.