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| Clinical study on early post-operational intraperitoneal chemotherapy and salviae in treating patients of gastric cancer |
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| KeyWord:gastric cancer, post operational stage, intraperitoneal chemotherapy, Radix Salviae Miltiorrhizae, 5 Fluorouracil |
| Author Name | Affiliation | | Qing-sheng Yu | Department of Surgery, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, (230031), Hefei | | Wei Wang | Department of Surgery, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, (230031), Hefei | | Xiao-ming Wang | Department of Surgery, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, (230031), Hefei | | Han-ming Wang | Department of Surgery, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, (230031), Hefei | | Jian-feng Shuai | Department of Surgery, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, (230031), Hefei |
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| Abstract: |
| Objective: To evaluate the safety, feasibility and short term efficacy of early post operational intraperitoneal chemotherapy (EPIC) combined with Salviae miltiorrhizae (SM) in treating patients with gastric cancer. Methods: The 136 patients enrolled were divided into 3 groups: the EPIC group, the EPVC group and the control group. The former two groups were treated with SM plus 5 FU started from the second or third day after operation for 5 continuous days by intraperitoneal infusion or intravenous dripping respectively, and the control group was untreated but conventional chemotherapy was given 3 weeks after surgical operation. Toxic and adverse effects of chemotherapy, post operational complications, short term survival rate and intra abdominal tumor recurrence rate were observed and compared.Results: (1) Toxic adverse effects of chemotherapy that occurred in the EPIC group were less than those in the EPVC group significantly ( P <0.05 0.01). (2) Occurrence of serious complications in the EPIC group was not higher than that in the other two groups. (3) The 1 and 2 year survival rate in the EPIC group was higher than those in the other two groups respectively ( P <0.01), while the post operational intra abdominal recurrence rate in EPIC group was significantly lower than that in the other two groups ( P <0.05). Conclusions: Combined therapy of SM and 5 FU in treating patients with gastric cancer by intraperitoneal infusion is not only safe and feasible with mild toxic and side effect, but also produces a more beneficial effects, including less intra abdominal recurrence and satisfactory short term survival rate . |
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