中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Effect of spirulina platensis polysaccharide on hematopoietic recovery and related cytokines in mice with transplanted tumor treated by chemotherapy

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KeyWord:Spirulina platensis, polysaccharide, transplanted tumor, myelosuppression, hematopoietic recovery, cytokines

Author Name	Affiliation	E-mail
Xiao-mei Liu	Institute of Medicine and Pharmacy, Yangzhou University, 225001, Yangzhou	liuxiaomei6@263.net
Hong-quan Zhang	Institute of Medicine and Pharmacy, Yangzhou University, 225001, Yangzhou

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Abstract:

Objective:To evaluate the effect of Spirulina platensis polysaccharide (SPP) on hematopoietic recovery and related cytokines in mice with transplanted tumor after chemotherapy. Methods:Mouse model of transplanted solid tumor was established and treated with chemotherapy. Peripheral blood cells, bone marrow nucleated cells, and colony forming unit-spleen (CFU-S) were counted; the content of DNA in bone marrow was inspected by ultraviolet spectrophotometer; serum content of cytokines, interleukin (IL)1, IL-3, granulocyte-macrophage colony stimulating factor (GM-CSF) and tumor necrosis factor-α (TNF-α) were determined by double antibody sandwich ELISA.Results:Cyclophosphamide (CTX) could induce evident myelosuppression, manifested as decrease of peripheral blood cells, bone marrow nucleated cell and DNA, and the CFU-S number. SPP could significantly ameliorate the myelosuppression induced by CTX without reducing anti-tumor effect of CTX. In addition, it could also increase the contents of IL-1, IL-3, GM-CSF, TNF-α in serum. Conclusion:SPP can probably accelerate the hematopoietic recovery in mice after chemotherapy through promoting endogenous secretion of cytokines.