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| Clinical study on effect of shenbing mixture in reducing recurrence of simple nephrotic syndrome of children |
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| Author Name | Affiliation | | Xin-min Li | Department of Pediatrics, The First Affiliated Hospital of Tianjin University of TCM, 300193, Tianjin | | Rong Ma | Department of Pediatrics, The First Affiliated Hospital of Tianjin University of TCM, 300193, Tianjin | | Shao-chuan Li | Department of Pediatrics, The First Affiliated Hospital of Tianjin University of TCM, 300193, Tianjin | | Xi-huan Sun | Department of Pediatrics, The First Affiliated Hospital of Tianjin University of TCM, 300193, Tianjin | | Rui-fang Hao | Department of Pediatrics, The First Affiliated Hospital of Tianjin University of TCM, 300193, Tianjin | | Qin Ren | Department of Pediatrics, The First Affiliated Hospital of Tianjin University of TCM, 300193, Tianjin | | Shu-ping Hu | Department of Pediatrics, The First Affiliated Hospital of Tianjin University of TCM, 300193, Tianjin | | Zhi-yi Yuan | Department of Pediatrics, The First Affiliated Hospital of Tianjin University of TCM, 300193, Tianjin |
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| Abstract: |
Objective To observe the effect of Shenbing Mixture (SBM) of the recurrence of simple nephrotic syndrome of children. Methods Sixty-eight patients treated with SBM combined with prednisone were observed and compared with those in the control group treated with prednisone alone. Results The 1-year recurrence rate of the treated group was 14. 3% , which was obviously lower than that in the control group (59.3%,P<0. 01). Serum level of Cortisol, IgG, IgA, CD3, CD4, CD4/ CD8 ratio and rosette formation rate of RBC-C3b in patients before treatment were all significantly lower than normal range. After being treated with SBM combined with prednisone, the above-mentioned indexes were all improved significantly and close to normal. Conclusion SBM had obvious effect in reducing recurrence of nephrotic syndrome in children, the mechanism is closely related to multiple pathways, including adjustment of T-lym-phocyte dysfunction, improving humoral immunity and RBC immune function, and promoting the recovery of adrenal cortex function. |
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