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| Clinical observation on effect of kesuning granule in treating acute onset of chronic bronchitis |
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| Author Name | Affiliation | | Bing Mao | West China Hospital, Sichuan University, 610041, Chengdu | | Rui-ming Zhang | West China Hospital, Sichuan University, 610041, Chengdu | | Ting-qian Li | West China Hospital, Sichuan University, 610041, Chengdu | | Guang-yuan Chen | West China Hospital, Sichuan University, 610041, Chengdu | | Jing Chang | West China Hospital, Sichuan University, 610041, Chengdu | | Qing Xia | West China Hospital, Sichuan University, 610041, Chengdu |
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| Abstract: |
Objective To prove the effect of Kesuning Granule (KSNG) in treating chronic bronchitis in exacerbation (Phlegm-Heat syndrome) and objectively evaluate its safety. Methods The double-blinded, double-dummy and randomized controlled method was adopted to observe 120 patients, who were divided into the treated group (n—60, treated with KSNG 8g, three times a day) and the control group (n=60, treated with Jinbei Tankeqing Granule (JBTKQ) 7g, three times a day). The therapeutic course for both groups was 6 days. Results In the treated group, the markedly effective rate was 58. 33% and effective rate was 93.33%, while in the control group, they were 51.67% and 91. 67% respectively, no significant difference was found between the two groups. For therapeutic effects on TCM syndromes, the markedly effective rate and effective rate in the treated group was 68. 33% and 93.33% respectively and in the control group, 66.67% and 90.00% respectively, also showed insignificant difference. The effect initiative time was earlier in the treated group than that in the control group significantly (P<0.05). No adverse effect was found in the observation. Conclusion KSNG shows a definite clinical effect with no obvious toxic-adverse effects. |
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