中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Zhi-yun Chen	Department of Digestive Disease, Zhejiang Provincial Hospital of TCM, 310006, Hangzhou
Mao-xiang Yan	Department of Digestive Disease, Zhejiang Provincial Hospital of TCM, 310006, Hangzhou
Bo-kang Xiang	Department of Digestive Disease, Zhejiang Provincial Hospital of TCM, 310006, Hangzhou

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Abstract:

Objective

To explore the changes of gut hormones in various TCM Syndrome types of irritable bowel syndrome (IBS) patients and its significance.

Methods

Ninety-four patients with IBS, whose diagnosis conformed to the Rome TJ diagnostic standard, were divided into three groups according to TCM Syndrome typing, i.e. the 42 patients in the Liver-Stagnancy with Spleen Deficiency (LSSD) group, 30 in the Spleen-Stomach Deficiency (SSD) group and 22 in the Spleen-Stomach Yin-Deficiency (SSYD) group. Plasma contents of neuro-peptide Y (NPY), substance P(SP), vascular active intestinal peptide (VIP) and pancreatic glucagon (Glu) of patients were determined by radioimmunoassay (RIA), and compared with those of the healthy persons.

Results

Blood contents of VIP and Glu in LSSD patients were higher than thosein the healthy control, NPY and SP were similar to thosein the healthy control, while NPY was higher and SP lower than that of SSYD patients respectively. In the SSD group, VIP and Glu.were higher than those of the healthy control, SP was lower than that in the control and in SSYD group, and NPY was different from the control insignificantly. In the SSYD group, SP and Glu was higher and NPY lower than those of control, while VIP was not significantly different from the control.

Conclusion

Some changes of gut hormones were presented in patients with IBS of various TCM Syndrome types, among them, the changes of NPY and SP showed Syndrome specificity, but changes of VIP and Glu did not show.